Li'l Wayne is equally responsible as any other entertainer or person, for that matter. Because he markets his music and videos to youth and because his antics land him headlining airtime on TV and the internet, he has a greater influence on youth than an ordinary person might, whether we like it or not.
I agree with GLASSJAW and his reference to making our youth more media literate through education at home and at school, but, we make too much adult content available to our youth these days.
The way a kid, and many adults, sees things... Li'l Wayne, and many, many other entertainers, promotes partying, cough syrup consumption, bitches, booze, drugs, sex, expensive cars, the importance of money, etc. Kids see this and they think this is how life is. They think this is how to act cool. Reality says this is not how real life is. It is how life is for many overpaid, over pampered, self-entitled Pop culture figures. A parent or teacher can model and tell a kid that this is not the way things are, but, a kid being a kid sometimes doesn't listen. They still want to be like Li'l Wayne because it's cool... It's what their culture says is cool... The flavor of the week. This is the parent's or teacher's problem how?
I disagree that kids see the artists and think that's how life is. I grew up with snoop dog, wu tang, 2pac, biggie and I never went around dealing drugs, doing drugs, shooting people ect ect.
There are bad influences everywhere that a kid can pick up on you can't control that. You can't tell people like lil Wayne how to live their life. Personally i think the internet is worst of all. who do we blame from every nasty thing being a google away?
In the end all you can do is have a positive impact on the people around you. As I said before and others have mentioned the parents play the most impostant role in all of this. I had a single parent who closely monitered my activities all the time.