nuckin_futz Posted September 1, 2022 Share Posted September 1, 2022 China's Chengdu and its 21 million population enters lockdown Chengdu is the largest city to enter lockdown since Shanghai earlier this year The move comes after the city reported 157 COVID-19 cases yesterday with mass testing to be conducted from Thursday to Sunday. All residents have been ordered to stay at home with households allowed to send a single person out, once per day, for groceries. But at least there is some leeway in the sense that people can leave the city but only after getting a negative test result within the past 24 hours. For some context, Chengdu houses a population of roughly 21 million and accounts for about 1.7% of China's GDP. There are quite a number of key manufacturing sites in the city such as Foxconn and Toyota. So, this just adds to more worries about supply disruptions and this comes after the news that Guangzhou and Shenzhen also tightened restrictions in the past week. 1 Link to comment Share on other sites More sharing options...
stawns Posted September 1, 2022 Share Posted September 1, 2022 9 hours ago, nuckin_futz said: China's Chengdu and its 21 million population enters lockdown Chengdu is the largest city to enter lockdown since Shanghai earlier this year The move comes after the city reported 157 COVID-19 cases yesterday with mass testing to be conducted from Thursday to Sunday. All residents have been ordered to stay at home with households allowed to send a single person out, once per day, for groceries. But at least there is some leeway in the sense that people can leave the city but only after getting a negative test result within the past 24 hours. For some context, Chengdu houses a population of roughly 21 million and accounts for about 1.7% of China's GDP. There are quite a number of key manufacturing sites in the city such as Foxconn and Toyota. So, this just adds to more worries about supply disruptions and this comes after the news that Guangzhou and Shenzhen also tightened restrictions in the past week. China's vaccines don't work, they have no choice, at this point, but to lock down Link to comment Share on other sites More sharing options...
Warhippy Posted September 1, 2022 Share Posted September 1, 2022 9 hours ago, nuckin_futz said: China's Chengdu and its 21 million population enters lockdown Chengdu is the largest city to enter lockdown since Shanghai earlier this year The move comes after the city reported 157 COVID-19 cases yesterday with mass testing to be conducted from Thursday to Sunday. All residents have been ordered to stay at home with households allowed to send a single person out, once per day, for groceries. But at least there is some leeway in the sense that people can leave the city but only after getting a negative test result within the past 24 hours. For some context, Chengdu houses a population of roughly 21 million and accounts for about 1.7% of China's GDP. There are quite a number of key manufacturing sites in the city such as Foxconn and Toyota. So, this just adds to more worries about supply disruptions and this comes after the news that Guangzhou and Shenzhen also tightened restrictions in the past week. To the inflation thread!! 1 Link to comment Share on other sites More sharing options...
thedestroyerofworlds Posted September 1, 2022 Share Posted September 1, 2022 https://globalnews.ca/news/9082286/health-canada-moderna-bivalent-vaccine-approval/ Health Canada approves Moderna’s Omicron COVID booster 1 1 Link to comment Share on other sites More sharing options...
JM_ Posted September 1, 2022 Share Posted September 1, 2022 2 hours ago, stawns said: China's vaccines don't work, they have no choice, at this point, but to lock down if only they could have partnered with a country willing to help them.... 1 Link to comment Share on other sites More sharing options...
Warhippy Posted September 1, 2022 Share Posted September 1, 2022 1 hour ago, JM_ said: if only they could have partnered with a country willing to help them.... They didn't need help, they felt comfortable with the secrets they'd stolen as being viable. 1 Link to comment Share on other sites More sharing options...
JM_ Posted September 1, 2022 Share Posted September 1, 2022 2 hours ago, Warhippy said: They didn't need help, they felt comfortable with the secrets they'd stolen as being viable. thats probably true. Link to comment Share on other sites More sharing options...
-Vintage Canuck- Posted September 2, 2022 Share Posted September 2, 2022 2 Link to comment Share on other sites More sharing options...
-Vintage Canuck- Posted September 7, 2022 Share Posted September 7, 2022 2 Link to comment Share on other sites More sharing options...
brilac Posted September 7, 2022 Share Posted September 7, 2022 (edited) Getting a second booster shot has been on my mind, but I have not heard further details about it in WA state/USA. It's the information that I am lacking. I've carried on with my life and have gotten back to most of the things I did three years ago. In a few weeks I am taking a day trip via airplane. The information -Vintage Canuck- provided above gives me more information of what B.C. is doing, and perhaps I should call the King County Health Department and talk to them and get more information about a second booster, etc. Edited September 7, 2022 by brilac 2 1 Link to comment Share on other sites More sharing options...
ronthecivil Posted September 7, 2022 Share Posted September 7, 2022 Won't they just text me when it's time? It's what they did that last two times.... Link to comment Share on other sites More sharing options...
Gurn Posted September 7, 2022 Share Posted September 7, 2022 7 minutes ago, ronthecivil said: Won't they just text me when it's time? It's what they did that last two times.... That is what they told me, by email in my case, but my buddy gets texts. However we are B.C. residents while brilac lives in the states, so she has some leg work to do. Link to comment Share on other sites More sharing options...
Playoff Beered Posted September 7, 2022 Share Posted September 7, 2022 (edited) An Antibody from Single Human VH-rearranging Mouse Neutralizes All SARS-CoV-2 Variants Through BA.5 by Inhibiting Membrane Fusion https://www.science.org/doi/10.1126/sciimmunol.add5446 Here is an article written about this for those that don't have a science degree... https://www.prevention.com/health/a41092334/antibody-neutralize-covid-variants/ Edited September 7, 2022 by Playoff Beered Link to comment Share on other sites More sharing options...
thedestroyerofworlds Posted September 8, 2022 Share Posted September 8, 2022 Here is a review article in the New England Journal of Medicine https://www.nejm.org/doi/full/10.1056/NEJMra2206573?query=recirc_mostViewed_railB_article Covid-19 Vaccines — Immunity, Variants, Boosters 2 Link to comment Share on other sites More sharing options...
CBH1926 Posted September 9, 2022 Author Share Posted September 9, 2022 I finally got Covid 19 after avoiding it all this time. 2 Link to comment Share on other sites More sharing options...
LTC123 Posted September 10, 2022 Share Posted September 10, 2022 excess deaths? are there excess deaths like I keep hearing about? young athletes "seem" to be falling over dead? If there are indeed excess deaths: why? how? Link to comment Share on other sites More sharing options...
Alflives Posted September 10, 2022 Share Posted September 10, 2022 18 minutes ago, LTC123 said: excess deaths? are there excess deaths like I keep hearing about? young athletes "seem" to be falling over dead? If there are indeed excess deaths: why? how? We know Covid effects some people (like Sutter) with long term illness. But he caught the illness before getting vaccinated, so had no protection. 1 Link to comment Share on other sites More sharing options...
bishopshodan Posted September 10, 2022 Share Posted September 10, 2022 1 hour ago, LTC123 said: excess deaths? are there excess deaths like I keep hearing about? young athletes "seem" to be falling over dead? If there are indeed excess deaths: why? how? From the vax or covid? What young athletes are you hearing about? Can you link something? Link to comment Share on other sites More sharing options...
thedestroyerofworlds Posted September 10, 2022 Share Posted September 10, 2022 (edited) 1 hour ago, LTC123 said: excess deaths? are there excess deaths like I keep hearing about? young athletes "seem" to be falling over dead? If there are indeed excess deaths: why? how? I think that term is referring to the fact that there were more deaths than expected. Thus excess deaths. As you can see, the US typically would have expected just under 3 million deaths in 2020 but had over 3.3 million deaths. An excess of probably around 400,000. Those excess deaths can really only be accounted for with Covid being the reason. And BTW, similar numbers can be had for 2021, with overdoses seeing an increase. However, that increase in overdose deaths is nowhere near that of Covid deaths. EDIT: The blue bar graph is provisional 2021 leading causes of deaths in the US https://www.cdc.gov/mmwr/volumes/71/wr/mm7117e1.htm#T1_down Edited September 10, 2022 by thedestroyerofworlds Link to comment Share on other sites More sharing options...
thedestroyerofworlds Posted September 12, 2022 Share Posted September 12, 2022 Couple articles on Covid vaccinations and kids. One is the article from the New England Journal of Medicine. The other is a breakdown/opinion piece about the study. Take away, vaccinate your kids. https://www.nejm.org/doi/full/10.1056/NEJMc2209371 Effects of Vaccination and Previous Infection on Omicron Infections in Children https://insidemedicine.bulletin.com/the-debate-on-covid-vaccines-for-school-aged-children-is-over-the-vaccines-won Opinion: The debate on Covid vaccines for school-aged children is over. The vaccines won. Zero vaccinated children died of Covid, while 7 unvaccinated kids died, large North Carolina study finds. Vaccines also provided protection against hospitalization—but so did prior infections. Do Covid vaccines really help school-aged kids that much? Yes, a study in the New England Journal of Medicine reports, based on real-world data from North Carolina. We also now have enough data on serious side effects to conclude that the benefits far outweigh exceedingly rare risks in this age group. The debate is over. Covid vaccines won. Covid vaccines were authorized for children ages 5-11 based on antibody data which implied that the lower dose that this group received would provide similar levels of protection against severe disease and death as seen among older trial participants earlier in the pandemic. While some data has already been published showing that real-world outcomes are favorable in preventing hospitalizations, this latest study packed in a lot more data and, importantly, focused on the Omicron period through June, providing us with key readouts reflecting the world we now live in. Here are questions and answers on what we know about Covid vaccines among children 5-11, based on this most recent data drop and other data sources. Was there a difference in mortality? Yes. 7 children died of Covid during the study. All 7 were among the 614,000 children who were unvaccinated. If the mortality rate seen during Omicron were to be applied nationally and amortized over a 1-year period, Covid-19 might be the 3rd leading cause of death in children ages 5-11, and certainly in the top 5, which it currently is, nationally for the year 2022 so far. By the way, has anyone else noticed that Covid is in the top 5 leading underlying causes of death among US children ages <1, 1-4, 5-11, and 7th among those aged 12-17? Well, it is. That’s just messed up. Did any children with prior infection die on reinfection? No. That’s good news for prior infection survivors. Was there a difference in hospitalization? Yes. By around 3 weeks after the first dose, Pfizer’s vaccine was 80% effective against hospitalization, peaking at 88% at week 4, and then slowly falling to 76% by week 20. That’s excellent news. (Note: most children received 2 doses). Pfizer-BioNTech's vaccine shows protection against Covid hospitalizations that peaks at 4 weeks, but remains effective long after that. Data: New England Journal of Medicine. Did any children with prior infection die or get hospitalized if reinfected? No deaths and not many hospitalizations. Even 10 months out, prior infection was highly protective against hospitalization on reinfection, although the confidence intervals (margins of error, so to speak), were very wide. One thing we do not know is how many of these children had hybrid immunity (i.e., a prior infection and a vaccination, either before or after). Because we don’t know how much overlap there was, we do not know whether prior infection was superior to vaccination in protecting against hospitalization. But even if a previous infection were superior to vaccination in protecting against infection, that wouldn’t be a reason for children not to be vaccinated, because hybrid immunity appears to be the strongest combination in most studies, including this one. If most kids have now been infected with coronavirus, are the vaccines even doing much? Though prior infection certainly confers protection against severe disease and death, there’s one very clear sign that the vaccines were still useful during the Omicron period that this study covers: the effectiveness of the vaccines in preventing hospitalization clearly increased during the first 4 weeks of the study. If all the kids in the study were already protected, we would not see such a steep rise in effectiveness in each successive week after vaccination. But we did. Effectiveness against hospitalization rose; 41% at week 1, 66% at week 2, 80% at week 3, 88% at week 4, and then slowly falling to 76-79% effective by 16-20 weeks. That’s not the signal of a vaccine that’s just along for the ride. The curves split too late and the slight fade (while not what we want), also tells us that this was unlikely just a bunch of confounded findings. How frequent were kids hospitalized for Covid? A lot more often than many realize. 1 in 200 unvaccinated infected children with known outcomes were hospitalized compared to 1 in 1,000 among infected vaccinated children. But the problem with these numbers is that we don’t really know how many cases there truly were because there was not anything close to universal testing. That’s why an important metric to look at ignores infection altogether, and instead asks, “how many kids were hospitalized in the entire unvaccinated versus vaccinated population?” Among the unvaccinated cohort, 1 in 2,089 children ages 5-11 were hospitalized for Covid, compared to just 1 in 15,208 among the vaccinated. That would seem to imply vaccine effectiveness against hospitalization of over 86%. Were the deaths for Covid or with Covid? Covid deaths only counted if they were judged to be the underlying cause. That means that if a child died for other reasons but had Covid, those deaths did not count. That’s appropriate since it would not be fair to blame Covid for a car accident that occurred when the victim happened to have Covid. Were the hospitalizations for Covid or with Covid? Hospitalizations only counted if Covid was the primary reason for the hospitalization. We know that both because the authors told us this, and also because the rate of hospitalizations during the overall study period was far too low to simply be a reflection of background rates. Did boosters matter? Probably, but the numbers are too small to be reliable and the follow-up period too short for any conclusions to be meaningful. At the time of publication, zero boosted children in the North Carolina study had been hospitalized and only a tiny fraction had been infected. The number of boosted children who got infected was so low that we have to assume that these kids were still quite close to their booster doses. We know that boosters pack a punch for weeks and even a couple of months before fading with respect to infection. Therefore, these data are not interpretable for comparing 2 versus 3 doses. If my child gets Covid, how long are they protected against another infection? Delta and Omicron markedly changed this (as I first noticed in Inside Medicine a year ago). A prior infection with a pre-Delta variant (among the unvaccinated) reduced infections by 98% in the month after infection, dropping below 60% only after 14 months. With a Delta infection (unvaccinated), future infections were reduced by 96% after a month, dropping below 60% after just 7 months. With an Omicron infection (unvaccinated), the early protection was 96% before dropping to under 60% by 5 months after infection. (It’s the variants, people.) Meanwhile, among the vaccinated children, a Delta infection meant a reduction in future infections by 96% at first, dropping to 75% by 4 months, and 53% by 5 months. An Omicron infection among vaccinated children started out with 97% reductions after the first month, dipping below 80% by 4 months, and 61% by 5 months. In the Omicron era, unvaccinated children who get infected can expect reductions in future infections in the 91-97% range for 2 months before dropping from 72% (month 3) down to 51% (month 5). Meanwhile vaccinated children can expect 94-97% reductions for 2 months, and 79-89% reductions during the 3rd and 4th months, and 61% reductions 5 months out. Have children ages 5-11 had myocarditis because of the vaccines? Almost none. The vaccine-associated myocarditis rate appears to be 1 in 314,615 in males and 1 in 1.43 million in females in children ages 5-11. The peak risk of myocarditis has been among 16-17-year-old males after the 2nd dose (at 1 in 12,600), a rate high enough to warrant an aside here. Despite that risk, the 2-dose series is still safer, because of how many Covid hospitalizations are prevented. With respect to boosters, the myocarditis rate in 16-17-year-old males turned out to be far lower, at 1 in 39,370. However, the rate of Covid hospitalization after 2 doses is so low, that the number of these kids we’d need to boost to notice any hospitalization benefit is actually so high that we might see as many myocarditis cases as saved Covid hospitalizations, depending on how the boosters perform and over what time period. Will the new “Omicron-specific” booster help? The new 2-in-1 “bivalent booster” combines some of the original vaccine with Omicron-specific components. We don’t know how much better it will perform and for how long. Summary: The debate is over, folks. Covid vaccines help reduce the bad outcomes in school-aged children that everyone cares about. If reducing death is what matters to you, the vaccines work. If reducing hospitalization is what matters to you, the vaccines work. If reducing infection is what matters to you, the vaccines work. Whether boosters help this age group on all of these metrics is less clear. The CDC recommends boosters for children ages 5-11, but that’s because they decrease infections temporarily. We don’t have data to show that boosters add protection against severe disease or death, in large part because the 2-dose series is just so effective for children (and even most young and middle-aged adults) in preventing those outcomes. For parents who were waiting for more real-world data before getting their school-aged children Covid vaccinations, your wait is over. Link to comment Share on other sites More sharing options...
Recommended Posts
Please sign in to comment
You will be able to leave a comment after signing in
Sign In Now